I'm very pleased to announce the release of NWSGI 1.0. NWSGI is an implementation of the WSGI specification (PEP 333) for IronPython. It is implemented as an ASP.NET HttpHandler and is supported on IIS 6 and IIS 7 (and should work on any other ASP.NET-capable web server). NWSGI allows the integration of Python applications with existing ASP.NET facilities such as caching, sessions, and user management.
This release does not mean that any Python application will work. The underlying IronPython 2.0 engine is not yet complete. It is a nearly-complete implementation of the NWSGI specification, and any app that takes IronPython's limitations into account should work just fine.
NWSGI fully supports xcopy deployment and medium trust environments (with the caveat that parts of the Python standard library are not supported). There is also an installer available that provides a managment UI for IIS 7.
NWSGI requires IIS (6 or 7), IronPython 2.0, and .NET Framework 2.0 SP1. All downloads include the NWSGI assembly, basic documentation, and a HelloWorld sample. The installers also include the IIS management UI.
Documentation is currently a weak spot, but I hope to improve that in the near future. In the meantime there is a README included, as well as some basic documentation at the NWSGI website.